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These investigations provide insights into the metabolic regulation of contractile adaptation and the cellular mechanisms underlying activity-induced metabolic remodeling in muscle tissue across different experimental conditions

The term SPECT mult indicates multiple images obtained during both a rest phase and a stress phase

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The original genetic-validation study used antisense oligonucleotide-mediated knockdown of NNMT in adipose tissue of mice on a high-fat diet, with whole-body and adipose-tissue metabolic endpoints measured against scrambled-oligonucleotide controls [2]